An amine-to-thiol crosslinker with medium-length aliphatic spacer arm

N-ε-Maleimidocaproyl oxysuccinimide ester
(EMCS)

An amine-to-thiol crosslinker with medium-length aliphatic spacer arm

Primetech LLC launches a new heterobifunctional crosslinker, N-ε-maleimidocaproyl oxysuccinimide ester (EMCS), which contains an NHS ester on one end and a maleimide group on the other one. The molecule contains a linear 6-carbon spacer, resulting in 9,4 Å crosslinks between biomolecules.

Highlights:

NHS ester couples with primary amines at pH 7-9, producing stable amide bonds
Maleimides react to thiol groups at pH 6.5-7.5, forming thioether linkages
Non-cleavable, soluble in DMSO, DMF
Aliphatic spacer has low potential for eliciting an immune response
Increased arm length vs. analogous reagents

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COMMENTS 0 & 02-05-2012, 10:24 # Author

New Catalogue 2011.

Primetech presents new Catalogue 2011!
Click here to download pdf or to browse on-line

COMMENTS 0 & 25-02-2011, 10:19 # Author

Primetech present two new products for bioconjugation by means of “click”-chemistry.

These two activated (NHS) esters allow introducing azido- and terminal alkyno-function into proteins, peptides or amino-modified oligonucleotides for the subsequent conjugation with each other as well as with fluorescent dyes, modified nano-particles or for immobilization onto modified surfaces.
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COMMENTS 0 & 28-03-2010, 19:36 # Author

We are glad to note that since 2009 Primetech LLC present a Stratagene company in Belarus. The full spectrum of equipment, reagents and materials you can find at www.stratagene.com

COMMENTS 0 & 20-12-2008, 20:36 # Author